NP 603 , a novel and potent inhibitor of FGFR 1 tyrosine kinase , 1 inhibits hepatic stellate cell proliferation and ameliorates hepatic 2 fibrosis in rats 3
نویسندگان
چکیده
fibrosis in rats 3 Nan Lin, Si Chen, Weidong Pan ,Linan Xu, Kunpeng Hu, Ruiyun Xu 4 5 1.Department of Hepatobiliary Surgery, the Third Affiliated Hospital, Sun 6 Yat-Sen University, GuangZhou 510630, PR China 7 2.Department of Immunology, Anhui Medical University, HeFei 230032,PR 8 China 9 3 Department of Gynecology and Obstetrics, the First Affiliated Hospital, 10 SunYat-Sen University, GuangZhou 510089, PR China 11
منابع مشابه
NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats.
Fibroblast growth factor 2 (FGF-2) and its main receptor FGFR1 have been shown to promote hepatic stellate cell (HSC) activation and proliferation. However, scant information is available on the anti-fibrogenic activity of FGFR1 inhibitors. The aim of this study was to assess the impact of a selective FGFR1 tyrosine kinase inhibitor NP603 on HSC proliferation and hepatic fibrosis. We demonstrat...
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